病原真菌次生代谢产物遗传调控，病原微生物致病机理研究，虫媒植物新病原筛选等。

本科教学：

 植物学，普通生物学，免疫学

研究生教学：

分子免疫学

1.  国家自然科学基金面上项目（32470207）：基于“COMPASS-SNF2-AGC”信号通路的黄曲霉毒素合成调控机制研究。主持

1.  国家自然科学基金面上项目（32070140）：以Set1为核心的COMPASS甲基转移酶复合体调控黄曲霉毒素合成的分子机理。主持

2.  福建省自然科学基金重点项目（2021J02026）：含SET结构域甲基转移酶调控黄曲霉产毒致病分子机制。主持

3.  国家重点研发计划项目子课题（2019YFC1200505）：病媒生物反向病原学监测及新传染病时空传播风险预测预警研究。主持

4.  福建省自然科学基金资助项目：黄曲霉bre2基因介导的组蛋白甲基化表观遗传调控机理研究（2017J01426）。主持

5.  福建省农业五新工程项目：基于基因工程抗体的黄曲霉毒素新型检测试剂盒。主持。

6.  福建农林大学杰出青年科技人才培养项目：次生代谢产物和形态建成调节基因mtfA在黄曲霉中生物学功能研究（xjq201410）。主持

7.  国家自然科学基金：小白鼠肝脏AFB1 膜结合蛋白的筛选和功能鉴定（31000961）。主持。

8.  福建省社会发展重点项目：食品中主要真菌毒素检测技术和检测试剂盒研发（2013Y0004）。主持。

9.  福建省高等学校新世纪优秀人才支持计划：伏马毒素B1等主要真菌毒素检测技术研发（JA13087）。主持。

10.福建省自然科学基金：黄曲霉毒素B1胁迫下与肝脏癌变相关线粒体比较蛋白质组学研究（2010J01068）。主持。

福建省自然科学基金项目：抗黄曲霉素单链抗体基因的克隆及其转化花生的研究（B0410010）。主持。

Wang J, Fu W, Ma X, Chen L, Song W, Ling S, Qian H, Wang SH* and Zhuang ZH*. Development of Latex Microsphere-Based Immunochromatographic Strips for Detecting Key Aflatoxins. Toxins 2025, 17, 426. https://doi.org/10.3390/toxins17090426. 2025.

Xie R§, Zhuang ZH§, Chen Q, Xie C, Adejor J, Nie X, Wang S. STA regulates succinylated AflM triggered by SCS to contribute to aflatoxin biosynthesis through the Ach1. Virulence. 16(1):2532812. doi: 10.1080/21505594.2025.2532812. 2025.

Ye K, Zhou S, Wu D, Ma D, Yao Y, Yang C, Sun M, Yang S, Fu W, Xin W, Yuan J*, Zhuang ZH*, Yang Y*. Molecular Mechanism of Aflatoxin B1 Synthesis Related AfVerB Regulating the Development, AFB1 Biosyntheis and Virulence of Aspergillus flavus Mainly Through Its CYP Domain. J Fungi (Basel). 11(4):293. doi: 10.3390/jof11040293. 2025.

Wu D, Yang C, Yao Y, Ma D, Lin H, Hao L, Xin W, Ye K, Sun M, Hu Y, Yang Y*, Zhuang ZH*. SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus. eLife.13:RP94743. doi: 10.7554/eLife.94743. 2024.

Lin H, Song W, Ma D, Yang C, Yao Y, Liu R, Hao L, Wu D, Wang S, Jiang J, Xiong J, Ma R, Xiao J* and Zhuang ZH*. Screening and Characterization of a New Iflavirus Virus in the Fruit Tree Pest Pyrops candelaria. Insects. 15(8):625. doi: 10.3390/insects15080625. 2024.

Yang C, Wu D, Lin H, Ma D, Fu W, Yao Y, Pan X, Wang S*, Zhuang ZH*. Role of RNA Modifications, Especially m6A, in Aflatoxin Biosynthesis of Aspergillus flavus. J Agric Food Chem. 72(1): 726-741. doi: 10.1021/acs.jafc.3c05926. 2024.

Hao L, Zhang M, Yang C, Pan X, Wu D, Lin H, Ma D, Yao Y, Fu W, Chang J, Yang Y*, Zhuang ZH*. The epigenetic regulator Set9 harmonizes fungal development, secondary metabolism, and colonization capacity of Aspergillus flavus. Int J Food Microbiol. 403:110298. doi: 10.1016/j.ijfoodmicro.110298. 2023.

Pan X, Hao L, Yang C, Lin H, Wu D, Chen X, Zhang M, Ma D, Wang Y, Fu W, Yao Y, Wang S*, Zhuang ZH*. SWD1 epigenetically chords fungal morphogenesis, aflatoxin biosynthesis, metabolism, and virulence of Aspergillus flavus. J Hazard Mater. 455:131542. doi: 10.1016/j.jhazmat.2023.131542. 2023.

Tao Y, Ge Y, Yang J, Song W, Jin D, Lin H, Zheng H, Lu S, Luo W, Huang Y, Zhuang ZH*, Xu JG*. A novel phytopathogen Erwinia sorbitola sp. nov., isolated from the feces of ruddy shelducks. Front Cell Infect Microbiol. 13:1109634. doi: 10.3389/fcimb.2023.1109634. 2023.

Huang Z, Wu D, Yang S, Fu W, Ma D, Yao Y, Lin H, Yuan J, Yang Y, Zhuang ZH*. Regulation of Fungal Morphogenesis and Pathogenicity of Aspergillus flavus by Hexokinase AfHxk1 through Its Domain Hexokinase_2. J Fungi (Basel).  9(11):1077. doi: 10.3390/jof9111077.2023.

Zhuang ZH, Pan X, Zhang M, Liu Y, Huang C, Li Y, Hao L, Wang S*. Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungus Aspergillus flavus. Virulence. 13(1):1358-1378. doi: 10.1080/21505594.2022.2101218. 2022.

Zhang M, Lin G, Pan X, Song W, Tan C, Chen X, Yang Y*, and Zhuang ZH*.The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus. IMA Fungus, 12(1):12. doi: 10.1186/s43008-021-00062-2. 2021.

Liu Y , Zhang M, Xie R, Zhang F, Wang S, Pan X, Wang S*, Zhuang ZH*. The Methyltransferase AflSet1 Is Involved in Fungal Morphogenesis, AFB1 Biosynthesis, and Virulence of Aspergillus flavus. Frontiers in Microbiology, 11: 234. 2020.

Hu Y, Yang G, Zhang D, Liu Y, Li Y, Lin G, Guo Z, Wang S*, Zhuang ZH*. The PHD Transcription Factor Rum1 Regulates Morphogenesis and Aflatoxin Biosynthesis in Aspergillus flavus. Toxins (Basel), 10(7). pii: E301. doi: 10.3390/toxins10070301. 2018.

Yuan J, Chen Z, Guo ZQ, Li D, Zhang F, Shen J, Zhang Y, Wang S*, Zhuang ZH*. PbsB Regulates Morphogenesis, Aflatoxin B1 Biosynthesis, and Pathogenicity of Aspergillus flavus. Front Cell Infect Microbiol. 8:162. doi: 10.3389/fcimb.2018.00162. eCollection. 2018.

Yang Y, Huang Y, Zeng L, Gao Y, Li Y, Ji Y, Wang S, Jia K, Zhuang ZH*. Estradiol 17 beta-dehydrogenase 5 is involved in aflatoxin B1 transportation. Turk J Vet Anim Sci, 41: 482-9. 2017.

Li Y, He Y, Li X, Fasoyin OE, Hu Y, Liu Y, Yuan J, Zhuang ZH*, Wang S*. Histone Methyltransferase aflrmtA gene is involved in the morphogenesis, mycotoxin biosynthesis, and pathogenicity of Aspergillus flavus. Toxicon, 127:112-21. 2017.

Zhuang ZH, Lohmar JM, Satterlee T, Cary JW, Calvo AM*. The Master Transcription Factor MtfA Governs Aflatoxin Production, Morphological Development and Pathogenicity in the Fungus Aspergillus flavus. Toxins (Basel). 20; 8(1). pii: E29. doi: 10.3390/toxins8010029. 2016.

Zhuang ZH, Huang YL, Yang YL, Wang SH. Identification of AFB1-interacting proteins and interactions between RPSA and AFB1. J Hazard Mater.301:297-303. 2016.

Ling S, Wang R, Gu X, Wen C, Chen L, Chen Z, Chen QA, Xiao S, Yang Y, Zhuang ZH*, Wang S*. Rapid detection of fumonisin B1 using a colloidal gold immunoassay strip test in corn samples. Toxicon, 108: 210-215. 2015.

Zhuang ZH，Que S，Gao Y，Yuan J，Ye Z，Du M，Lin G，Liu L，Wang SH. Artificial antigen synthesis and the development of polyclonal antibody-based immunoassay for citreoviridin determination. World J MicrobiolBiotechnol，30(1): 343-349, 2014.

Zhuang ZH, Yang D, Huang Y,Wang SH. Study on the Apoptosis Mechanism Induced by T-2 Toxin. PLoS ONE, 8(12): e83105, 2014.

Zhuang ZH, Zhao X, Li H, Wang SY, Peng XX*. Gut CaVP is an innate immune protein against bacterial challenge in amphioxus Branchiostoma belcheri. Fish & Shellfish Immunology,31(2): 217-223, 2011.

Zhuang ZH, Li H, Yang J, Liu X, Gao YY, Li QF, Wang SY, Peng XX*. Gut SCP is an immue-relevant molecule involved in the primary immunological memory or pattern recognition in the amphioxus Branchiostoma belcheri. Fish & Shellfish Immunology. 30: 700-705, 2011.

庄振宏，林虹;宋卫涛，等，一种小核糖核酸属病毒的检测引物和检测方法; 2024.9, 中国，ZL 2022 1 1268287.7

庄振宏，刘亚举，胡育乐，等，一株不产黄曲霉毒素菌株ΔAflsnt2及防治黄曲霉污染的应用; 2021.3, 中国，ZL 201910107687.1

庄振宏，胡育乐，汪世华，等，一株不产黄曲霉毒素菌株的构建及防治黄曲霉污染的方法; 2020.6,中国，ZL 201810393424.7

庄振宏，黄亚玲，汪世华，等, 快速鉴定与黄曲霉毒素B1互作的宿主蛋白的方法；2015.7, 中国，ZL 201410031331.1

庄振宏，杨燕凌，汪世华，等，一种基因工程单链抗体伏马毒素B1的试剂盒及方法，2014.12  中国，ZL 2011 10027055.8

汪世华，庄振宏，袁军，等，一种基因工程单链抗体检测河豚毒素的试剂盒及方法，2013.10, 中国，ZL 201110027079.3

第十六届福建省自然科学优秀学术论文三等奖（The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus）2024