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工学博士，福建农林大学生命科学学院生物工程系教授，博士生导师，福建省高层次人才，中国生物化学与分子生物学会工业专业分会委员，福建省生物工程学会常务理事，福建省食用菌学会理事。2010年毕业于华东理工大学生物工程学院，2014-2015在Konkuk University工学院生物化工系任助理教授，目前主要从事中药资源生物技术、生物催化与转化、药效成分合成生物学等方面的研究。福建农林大学“金山学者”青年拔尖人才（2017）、“福建省高等学校新世纪优秀人才支持计划”（2015）、“福建省高校杰出青年科研人才计划”（2014）、“福建农林大学杰出青年科技人才”（2014）、福建农林大学“金山学者”青年学术新秀（2013）获得者，先后主持国家自然科学基金（3项）及省部级等科研项目10余项。以第一作者或通讯作者发表学术论文50余篇，其中SCI收录30余篇，以第一申请人申请发明专利8项。


个人信息

  • 行政职务：
  • 技术职称： 教授
  • 最后学位： 博士学位
  • 邮    编：
  • 电    话：
  • 电子邮箱： zliaoyuan@126.com
  • 办公地点： 下安实训中心1号楼107-108
  • 通讯地址： 福建省福州市仓山区福建农林大学生命科学学院

荣誉及奖励

全国大学生生命科学竞赛福建赛区三等奖（2024）指导老师

福建省研究生优秀学位论文（2023）指导老师

福建农林大学研究生优秀学位论文（2022）指导老师

全国大学生生命科学竞赛二等奖（2022）指导老师

全国大学生生命科学竞赛福建赛区特等奖（2022）指导老师

第二届福建省青年科普创新实验暨作品大赛三等奖（2022）指导老师

福建农林大学优秀教师（2021）

福建农林大学研究生优秀学位论文（2018）指导老师

福建省研究生优秀学位论文（2017）指导老师

福建农林大学研究生优秀学位论文（2017）指导老师

福建农林大学“金山学者”青年拔尖人才（2017）

神农福建农业科技奖二等奖（2017）排名第五

宁德市第一届农业科技推广奖二等奖 (2016) 排名第三

福建省高等学校新世纪优秀人才 (2015)

福建省科学技术进步三等奖 (2015) 排名第三

研究生“严家显”奖学金 (2014) 指导老师

福建农林大学青年五四奖章（2014）

福建农林大学杰出青年（2014）

福建农林大学“金山学者”青年学术新秀（2013）

研究生国家奖学金（2013）指导老师

大学生“挑战杯”科技创新福建省三等奖（2013）指导教师

大学生“挑战杯”科技创新校一等奖（2012）指导教师

院优秀班主任（2012）


研究领域

以中药资源为研究对象，聚焦药效成分生物合成途径关键酶的发现、催化机制解析、高效催化剂理性设计以及药效成分生物合成体系的构建。

研究方向：中药资源生物技术、生物催化与转化、代谢工程与合成生物学


开授课程

  1. 《生物反应工程》，本科生专业核心课，32学时

  2. 《发酵示范生产实习》，本科生专业实践课，120学时

  3. 《生物大分子与微生物组学》，博士研究生专业课，32学时


科研项目

1.       国家自然科学基金面上项目（82373990）（2024-2027）

2.       国家自然科学基金面上项目（81673542）（2017-2020）

3.       国家自然科学基金青年项目（31301858）（2014-2016）

4.       污水高效处理菌剂构建关键技术开发企业横向（2024-2025）

5.       代料栽培茯苓技术开发及中试企业横向（2023-2024）

6.       高品质银耳多糖提取关键技术研发企业横向（2022-2023）

7.       福建省种业工程子课题（2021-2025）

8.       福建省科技厅星火项目（2021-2022）

9.       福建省食用菌产业重大农技推广服务体系建设（KNJ15301E）（2016）

10.    福建省高等学校新世纪优秀人才支持计划（K8015056A）（2015-2017）

11.    福建农林大学杰出青年项目（xjq201408）（2014-2016）

12.    福建省高校杰出青年科研人才培育计划项目（JA14100）(2014-2016)

13.    教育部博士点基金（20133515120011）（2014-2016）

14.    生物反应器国家重点实验室开放课题（2012-2014）

15.    福建省生物产业技术专项（2011878）（2011-2014）

16.    福建省自然科学基金青年基金（2011J05048）（2011-2013）

17.    福建省教育厅科技项目（JA11089）（2011-2013）

论文著作

1.       Feng Zhang, Yu Gao, Enxi Ren, Ling Fang, Weijuan Yang, Liaoyuan Zhang*, Zongwen Wang*. Paper-based multicolor sensor for on-site quantitative detection of organophosphate pesticides based on acetylcholinesterase-mediated paper-based Au3+-etching of gold nanobipyramids and CIELab color space. Talanta, 2025, 281: 126925.

2.       Feng Zhang, Enxi Ren, Zemiao Wang, Ling Fang, Weijuan Yang, Liaoyuan Zhang*, Zongwen Wang*.  Portable paper-based multicolor sensor for sensitive on-site detection of organophosphorus pesticides using a high-efficiency Au+-induced gold nanobipyramids aspect ratio regulation strategy. Microchemical Journal, 2024, 207: 111912.

3.       Jiming Zhang†, Hui Lin†, Chaosong Zheng, Bin Yang, Miao Liang, Yi Lin*, Liaoyuan Zhang*. Efficient 2,3-Butanediol Production from Ethanol by a Modified Four-Enzyme Synthetic Biosystem. Molecules, 2024, 29: 3934.

4.       Yanhuan Lin, Changle Li, Chenxin Wei, Hui Lin*, Liaoyuan Zhang*. Mining, Identification, and Characterization of Three Xylanases from the Microbiota of T. fuciformis with Its Companion Strains. Catalysts, 2024, 14: 15.

5.       Hui Lin, Pengfei Li, Lu Ma, Shufang Lai, Shujing Sun, Kaihui Hu*, Liaoyuan Zhang*. Analysis and modification of central carbon metabolism in Hypsizygus marmoreus for improving mycelial growth performance and fruiting body yield. Frontiers in Microbiology, 2023, 14: 1233512.

6.       Zewang Guo, Denghui Chen, Qi Xiong, Miao Liang, Pengfei Li, Zehui Gong, Junzhi Qiu*, Liaoyuan Zhang*. Characterization of a new marine Leucine dehydrogenase from Pseudomonas balearica and its application for L-tert-leucine production. Catalysts, 2022, 12: 971.

7.       Wenting Wang, Xiaojie Lin, Huixiang Yang, Xiaoqin Huang, Lei Pan, Shaohua Wu, Chao Yang, Liaoyuan Zhang*, Yongyu Li*.Anti-quorum sensing evaluation of methyleugenol, the principal bioactive component, from the Melaleuca bracteata leaf oil. Frontiers in Microbiology, 2022, 13: 970520.

8.       Vipin Chandra Kalia*, Chunjie Gong, Ramasamy Shanmugam, Hui Lin, Liaoyuan Zhang*, Jung-Kul Lee*. The Emerging Biotherapeutic Agent Akkermansia. Indian Journal of Microbiology, 2022, 60(1): 1-10.

9.       Hui Lin†, Jiayin Xu†, Wenlian Sun, Wujia Hu, Huifang Gao, Kaihui Hu, Junzhi Qiu, Binbin Huang*, Liaoyuan Zhang*. Efficient 1-Hydroxy-2-Butanone Production from 1,2-Butanediol by Whole Cells of Engineered E. coli. Catalysts, 2021, 11(10):1184.

10.    Feilong Li, Wenbin Su, Qinglan Tao, Liaoyuan Zhang*, Yewang Zhang*. Expression, biochemical characterization, and mutation of a water forming NADH:FMN oxidoreductase from Lactobacillus rhamnosus. Enzyme and Microbial Technology, 2020, 134: 109464.

11.    Virendra Kumar, Sanjay K. S. Patel, Rahul K. Gupta, Sachin V. Otari, Hui Gao, Jung-Kul Lee*, Liaoyuan Zhang*. Enhanced Saccharification and Fermentation of Rice Straw by Reducing the Concentration of Phenolic Compounds, Using an Immobilized Enzyme Cocktail. Biotechnology Journal, 2019, 14: 1800468.

12.    Yongyu Li, Bingchun Guo, Wenting Wang, Liang Li, Lili Cao, Chao Yang, Jingyuan Liu, Qin Liang, Jianjun Chen*, Shaohua Wu*, Liaoyuan Zhang*. Characterization of phenolic compounds from Phyllanthus emblica fruits using HPLC-ESI-TOF-MS as affected by an optimized microwave-assisted extraction. International Journal of Food Properties, 2019, 22(1): 330-342.

13.    Wensong Jin†, Hui Lin†, Huifang Gao, Jiahuan Li, Quanming Xu, Shujing Sun, Kaihui Hu, Jung-Kul Lee*, Liaoyuan Zhang*. N-acyl-homoserine lactone quorum sensing switching the acidogenesis to solventogenesis during the fermentation process in Serratia marcescens MG1. Journal of Microbiology and Biotechnology, 2019, 29(4): 596-606.

14.    Fanbing Chen, Wensong Jin, Huifang Gao, Zewang Guo, Hui Lin, Jiahuan Li, Kaihui Hu, Xiong Guan, Vipin C. Kalia, Jung-Kul Lee*, LiaoyuanZhang*, Yongyu Li*. Cloning, Expression and Characterization of Two Beta Carbonic Anhydrases from a Newly Isolated CO2 Fixer, Serratia marcescens Wy064. Indian Journal of Microbiology, 2019, 59(1): 64-72.

15.    Liaoyuan Zhang*†, Raushan Singh†, Sivakumar D, Zewang Guo, Jiahuan Li, Fanbing Chen, Yuanzhi He, Xiong Guan, Yun Chan Kang*, Jung-Kul Lee*. An artificial synthetic pathway for acetoin, 2,3-butanediol and 2-butanol production from ethanol using cell free multi-enzymes catalysis. Green Chemistry, 2018, 20(1): 230-242.

16.    Yuanzhi He†, Feixue Chen†, Meijing Sun, Huifang Gao, Zewang Guo, Hui Lin, Jiebo Chen, Wensong Jin, Yunlong Yang, Liaoyuan Zhang*, Jun Yuan*. Efficient (3S)-Acetoin and (2S,3S)-2,3-Butanediol Production from meso-2,3-Butanediol Using Whole-Cell Biocatalysis. Molecules, 2018, 23(3): 691.

17.    Yongyu Li, Zhengmei Ye, Wenting Wang, Chao Yang, Jingyuan Liu, Liting Zhou, Yuze Shen, Zhiheng Wang, Jianjun Chen* Shaohua Wu*, Liaoyuan Zhang*. Composition analysis of essential oil from Melaleuca bracteata leaves using ultrasound-assisted extraction and its antioxidative and antimicrobial activities. Bioresources, 2018, 13(4): 8488-8504.

18.    Hui Lin, Meijing Sun, Jiahuan Li, Quanming Xu, Bin Yang, Qi Wang, Weijie Xie, Shujing Sun, Kaihui Hu*, Liaoyuan Zhang*. Purification and characterization of xylanase from spent mushroom compost and its application in saccharification of biomass wastes. Bioresources, 2018, 13(1): 220-230.

19.    Yongyu Li, Jianyan Chen, Lili Cao, Liang Li, Fang Wang, Zhengping, Liao, Jianjun Chen*, Shaohua Wu*, Liaoyuan Zhang*. Characterization of a novel polysaccharide isolated from Phyllanthus emblica L. and analysis of its antioxidant activities. Journal of Food Science and Technology, 2018,55(7): 2758-2764.

20.    Jun Yuan†, Yuanzhi He†, Zewang Guo, Huifang Gao, Fanbing Chen, Lizhi Li, Yongyu Li, Liaoyuan Zhang*. Utilization of sweet sorghum juice for efficient 2,3-butanediol production by Serratia marcescens H30. Bioresources, 2017, 12(3), 4926-4942.

21.    Sachin V. Otaria, Manoj Kumar, Muhammad Zahid Anwar, Nanasaheb D. Thorat, Sanjay K. S. Patel, Dongjin Lee, Jai Hyo Lee, Jung-Kul Lee*, Yun Chan Kang*, Liaoyuan Zhang*. Rapid synthesis and decoration of reduced graphene oxide with gold nanoparticles by thermostable peptides for memory device and photothermal applications. Scientific Reports, 2017, 7: 10980.

22.    S. V. Otari, S. H. Pawar, Sanjay K. S. Patel, Raushan K. Singh, Sang-Yong Kim, Jai Hyo Lee, Liaoyuan Zhang*, Jung-Kul Lee*. Canna edulis leaf extract-mediated preparation of stabilized silver nanoparticles: Characterization, antimicrobial activity, and toxicity studies. Journal of Microbiology and Biotechnology, 2017, 27(4): 731-738.

23.    Zewang Guo, Xihua Zhao, Yuanzhi He, Tianxing Yang, Huifang Gao, Ganxin Li, Feixue Chen, Meijing Sun, Jung-Kul Lee*, Liaoyuan Zhang*.Efficient (3R)-acetoin production from meso-2,3-butanediol using a new whole-cell biocatalyst with co-expression of meso-2,3-butanediol dehydrogenase, NADH oxidase and Vitreoscilla hemoglobin. Journal of Microbiology and Biotechnology, 2017, 27(1): 92-100.

24.    Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan*, Yaling Shen*. Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241. Scientific Reports, 2016, 6: 19257.

25.    Sanjay K. S. Patel, Jae-Hoon Jeong, Sanjeet Mehariya, Sachin V. Otari, Bharat Madan, Jung Rim Haw, Jung-Kul Lee*, Liaoyuan Zhang*, In-Won Kim*. Production of Methanol from Methane by Encapsulated Methylosinus sporium. Journal of Microbiology and Biotechnology, 2016, 26(12): 2098-2105.

26.    Xin Lv, Lu Dai, Fangmin Bai, Zhanqing Wang, Liaoyuan Zhang*, Yaling Shen*. Metabolic engineering of Serratia marcescens MG1 for enhanced production of production of (3R)-acetoin. Bioresources and Bioprocess. 2016, 3: 52.

27.    Liaoyuan Zhang, Zewang Guo, Huifang Gao, Xiaoqian Peng, Yongyu Li, Shujing Sun, Jung-Kul Lee*, Wenxiong Lin*. Interaction of Pseudostellaria heterophylla with quorum sensing and quorum quenching bacteria mediated by root exudates in a consecutive monoculture system. Journal of Microbiology and Biotechnology, 2016, 26(12): 2159-2170.

28.    Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*. Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin. Journal of Chemical Technology and Biotechnology. 2015, 90(1): 93-100.

29.    Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao, Liaoyuan Zhang*, Yaling Shen*. Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production. Journal of Industrial Microbiology and Biotechnology, 2015, 42(5): 779-786.

30.    Liaoyuan Zhang*. Enhanced 2,3-butanediol production by Serratia marcescens H30 with over-expression of 2,3-butanediol dehydrogenase. Research Journal of BioTechnology. 2015, 10(5): 82-87.

31.    Liaoyuan Zhang, Quanming Xu, Senran Zhan, Yongyu Li, Hui Lin, Shujing Sun, Li Sha, Kaihui Hu, Xiong Guan*, Yaling Shen*. A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30. Applied Microbiology and Biotechnology. 2014, 98(3): 1175-1184.

32.    Liaoyuan Zhang*, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yunlong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology. 2014, 41(9): 1319-1327.

33.    Liaoyuan Zhang*. Fermentation and evaluation of Serratia marcescens H30 and S. marcescens MG1 for 2,3-butanediol production. Research Journal of BioTechnology. 2014, 9(11): 32-37.

34.    Liaoyuan Zhang*, Senran Zhan, Lizhi Chen, Xiong Guan, Kaihui Hu. Screening of traditional Chinese edible fungi for quorum sensing inhibitors activity. Research Journal of BioTechnology. 2013, 8(10): 79-83.

35.    Liaoyuan Zhang, Shuang Chen, Haibo Xie, Yuting Tian, Kaihui Hu*. Efficient acetoin production by optimization of medium components and oxygen supply control using a newly isolated Paenibacillus polymyxa CS107. Journal of Chemical Technology and Biotechnology. 2012, 87(11): 1551-1557.

36.    Liaoyuan Zhang, Yunlong Yang, Jian’an Sun, Yaling Shen*, Dongzhi Wei*, Ju Chu. Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30. Bioresource Technology. 2010, 101:1961-1967.

37.    Liaoyuan Zhang, Jian’an Sun, Yingli Hao, Jiawen Zhu, Ju Chu, Dongzhi Wei*, Yaling Shen*. Microbial production of 2,3-butanediol by a surfactant (serrawettin)-deficient mutant of Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology. 2010, 37(8): 857-862.


科技成果