Linxiangmin Professor

We focused on the antibiotics resistance mechanisms of aquatic bacterial pathogens, such as Aeromonas hydrophila,Edwardsiella tardaand Vibrio parahaemolyticus,using proteomics technologies.

Aeromonas hydrophila is a causative agent of many aquatic animals and also is a kind of typical human-domestic anima-fish’s pathogens. Pathogenic A. hydrophila cause serious disease outbreaks in a variety of farmed fish, which lead to large economic losses in the aquaculture industry on an annual basis.

Undergraduate Course：Proteomics, Biological English

Postgraduate courses: Ecological Engilish  

2022-

[1] Lingli Lian^#, Lina Sun^#, Xinrui Zhao, Linxin Chen, Binghui Zhang, Yanling Liu, Xiangmin Lin *. Comprehensive analysis of pathogenicity factors in the highly virulent Aeromonas hydrophila strain LP-2. Aquaculture, 2025, 598:741982. 

[2] Guibin Wang, Linxin Chen, Juanqi Lian, Lanqing Gong, Feng Tian, Yuqian Wang, Xiangmin Lin *, Yanling Liu*. Proteomic insights into the regulatory role of CobQ deacetylase in Aeromonas hydrophila. Journal of Proteome Research, 2025,24,333-343.   

[3] Yuqian Wang, Guibin Wang, Lishan Zhang, Qilan Cai, Meizhen Lin, Dongping Huang, Yuyue Xie, Wenxiong Lin, Xiangmin Lin *. Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase. eLife, 2024, 13:RP97511

[4] Lishan Zhang, Yuying Fu, Qiaozhen Xu, Xin Chen, Yuyue Xie, Binghui Zhang, Xiangmin Lin *. Quantitative proteomics reveals the complex regulatory networks of LTTR-type regulators in pleiotropic functions of Aeromonas hydrophila.International Journal of Biological Macromolecules,2024, 270:132315.

[5] Shuangziying Zhang#, Wenxiao Yang#, Yuyue Xie, Xinrui Zhao, Haoyu Chen, Lishan Zhang, Xiangmin Lin*. Quantitative Proteomics Investigating the Intrinsic Adaptation Mechanism of Aeromonas hydrophila to Streptomycin. Proteomics,2024,2024, 24(19): 2300383.

[6] Xiaoyan Li，Feng Tian, Binghui Zhang, Lishan Zhang, Xiaomeng Chen, Xiaoke Lin, Yuqian Wang, Xiangmin Lin*, Yanling Liu*.Quantitative proteomics analysis reveals an important role of the transcriptional regulator UidR in the bacterial biofilm formation of Aeromonas hydrophila.Frontiers in Cellular and Infection Microbiology, 2024,14:1380747

[7] Yuying Fu, Lishan Zhang, Yi Lin, Xinrui Zhao, Haoyu Chen, Yicheng Zhong, Wenjia Jiang, Xiaoyun Wu, Xiangmin Lin*. Unveiling the antibacterial mechanism of resveratrol against Aeromonas hydrophila through proteomics analysis. Frontiers in Cellular and Infection Microbiology, 2024,14:1378094

[8] Lishan Zhang, Lina Sun, Ramanathan Srinivasan, Meizhen Lin, Lanqing Gong, Xiangmin Lin *. Unveiling a virulence-regulating mechanism in Aeromonas hydrophila: a quantitative exoproteomic analysis of an AraC-like protein. Frontiers in Immunology, 2023, 14:1191209. 

[9] Ziqiu Liu, Lishan Zhang, Qingli Song, Huanhan Song, Yunqi Xu, Jinlian Lu, Qiaozhen Xu, Yuze Tang, Guibin Wang, Xiangmin Lin *. Quantitative proteomics reveal the inherent antibiotic resistance mechanism against norfloxacin resistance in Aeromonas hydrophlia.Journal of Proteome Research, 2023, 22, 4, 1193-1200.

[10]Qingli Song^#, Lishan Zhang^#, Guibin Wang, Huanhuan Song, Shuangziying Zhang, Jindong Yao, Xiangmin Lin*.Proteomics analysis reveals that CirA in Aeromonas hydrophila is involved in nutrient uptake. Environmental Microbiology,2023, 25,5:977-989.

[11] Yanling Liu, Yao Wu, Ramanathan Srinivasan, Ziqiu Liu, Yuqian Wang, Lishan Zhang, Xiangmin Lin*.The protective efficacy of forty outer membrane proteins based DNA vaccines against Aeromonas hydrophila in zebrafish. Aquaculture Reports, 2022, 27, 101381.

[12] Lishan Zhang^#, Yao Wu^#, Zujie Yao, Xiaoyun Wang, Jiazhen Chen, Wenxiao Yang, Jindong Yao, Yuexu Lin, Zhu Liu, Xiangmin Lin*. A novel, high-throughput screen for bacterial quorum sensing inhibitors (QSIs) combined with phage peptide display libraries and QSI reporter.Aquaculture, 2022,560, 738488.

[13] Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin*. The lysine acetylation modification in the porin Aha1 of Aeromonas hydrophila regulates the uptake of multi-drug antibiotics. Molecular & Cellular Proteomics, 2022, 21, 100248.

[14] Ling Lin^#, Yuqian Wang^#, Ramanathan Srinivasan, Lishan Zhang, Huanhuan Song, Qingli Song, Guibin Wang, Xiangmin Lin*. Quantitative proteomics reveals that the protein components of outer membrane vesicles (OMVs) in Aeromonas hydrophila play protective roles in antibiotic resistance. Journal of Proteome Research, 2022,21, 7, 1707-1717. 

[15] Lishan Zhang^#, Xiaomeng Chen^#, Guibin Wang, Jindong Yao, Jin Wei, Zhu Liu, Xiangmin Lin*, Yanling Liu*. Quantitative proteomics reveals the antibiotics adaptation mechanism of Aeromonas hydrophila under kanamycin stress. Journal of Proteomics, 2022, 264,104621.